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In today’s session on fungal infections we focussed on discussing the mechanisms of action, pharmacokinetics and spectrums of activity of the different antifungal agents and then applied the knowledge to two cases. The classes of medications we discussed included: Echinocandins, azoles, pyrimidines and polyenes. I learned that the azoles have the broadest spectrum of activity with posaconazole  having the most coverage. AmB is also very effective for candida species and Cryptococcus and the echinocandins are best for aspergillus and candida infections.  We also discussed the differences in absorption for the azoles and how voriconazole is best absorbed on an empty stomach which is the opposite of posaconazole which is best absorbed with a high fat meal.

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